PROGRAM FOR PLASMA SEPARATION WITH HYALURONIC ACID. INNOVATION IN ADVANCED AGING THERAPY.
The synergistic combination of non-cross-linked hyaluronic acid conglomerate with highly regenerative platelet-rich plasma allows for multi-level redermalization of the skin and maximization of tissue biochemical processes. Fusion PRP is an effective inhibitor of collagen and elastin synthesis and a stimulator of tissue restructuring. It ensures intensive regeneration of connective tissue and the skin support frame, firms and lifts the skin for a long time.
DIVES MED FUSION PRP is a specialized system for obtaining and reimplantation of Platelet Rich Plasma enriched with hyaluronic acid for the purpose of intensive bio stimulation of skin cells. The use of a specialized DIVES MED FUSION PRP kit allows to obtain platelet-rich plasma (PRP), i.e., an autologous blood-derivative containing a conglomerate of non-cross-linked hyaluronic acid. The PRP-HA concentrate is obtained by taking blood directly from the patient and its subsequent centrifugation. The centrifugation process separates individual blood cells according to their weight and separates the HA, PLT (platelets) and plasma fractions. As a result, we obtain a highly concentrated PRP concentrate with HA with a remarkably regenerating and rejuvenating effect, which we reimplant into the patient’s body. This triggers a series of auto-repair reactions, activation of fibroblasts for collagen synthesis, active angiogenesis, and stimulation of mesenchymal stem cells. The main advantage of the therapy is its autologous safety, with no risk of allergies, intolerance, or rejection.
The DIVES MED FUSION PRP kit includes two 10 ml sterile polycarbonate vacuum tubes with 2 ml of hyaluronic acid, a separating gel, and an anticoagulant solution. The set includes two sets of treatment instruments.
Tubes allow a vacuum, completely closed blood collection system, which increases the safety of the procedure and prevents material contamination
ACD + SEPARATOR GEL
Filled with ACD anticoagulant solution (sodium citrate, citric acid, glucose) and separating gel
HYALURONIC ACID ADDITION CЄ1023
Filled with non-cross-linked hyaluronic acid in a volume of 2 ml and a concentration of 16 mg / ml, increasing the effectiveness of the treatment
The production of medical polycarbonate tubes maximizes the level of platelets in the PRP concentrate and increases the effectiveness of the therapy
Each of the tubes is packed in a separate blister, which allows the set to be divided into 2 independent treatments
– Pregnancy and lactation
– Active viral and bacterial infection
– Blood diseases
– Taking medications that impair blood clotting and NSAIDs
– Acute conditions in the course of autoimmune diseases
HOW TO USE
Stage 1: Collection of Whole Blood
Before starting blood sampling, disinfect the skin. Open the set of treatment instruments and the blister with the tube. Make a venous puncture with the included phlebotomy accessories, then connect the tube with the holder. The test tube will start to fill with blood automatically, up to a volume of about 6 ml. After filling, disconnect the tube and, if necessary, attach another. Turn the obtained test tubes upside down several times in order to mix the blood with the anticoagulant solution. Place contaminated collection instruments in a medical waste container and dispose of according to procedures for handling blood-contaminated materials.
Stage 2: Centrifugation
Place the received test tube in the centrifuge. On the opposite side, sweep a counterweight filled with water or another blood tube to balance the device. Centrifuge for 12 minutes at 1800 g centrifugal force (RCF). Set the rotational speed (RPM) according to the recommendations of the manufacturers of the centrifuge.
Stage 3: PRP Collection
The centrifugal force will arrange the morphotic parts according to the gravitational weight and obtain 4 fractions. There will be red blood cells at the bottom of the test tube, a separating gel above them, plasma (PRP and PPP) on top of them, and hyaluronic acid (HA) conglomerate on top. Turn the test tube upside down several times, which will allow the plate concentrate to mix with hyaluronic acid. Mixing the PRP phase with the HA will result in a platelet-rich plasma enriched in hyaluronic acid. Use a 20G 0.9x70mm needle and draw the resulting solution directly into the syringe. The contained separating gel is not intended for injection. From the separation of 1 test tube, you will receive a total of about 5 ml of platelet-rich plasma enriched with hyaluronic acid.
Stage 4: Injection
Immediately apply the resulting solution to the tissues. Administering the concentrate within 30
minutes from the moment of collection ensures full biological activity of the solution. It is possible to
use some or all of the obtained preparation.
Stage 5: Disposal
After use, dispose of all components of the procedure set in accordance with the guidelines for handling materials potentially contaminated with blood. Use caution against unprotected needles and other contaminated treatment instruments.
DOSAGE AND INJECTION METHOD:
Joint space injections should be performed with medical imaging and with the same precautions as for any other intra-articular injection. Immediately after the injection, the patient should refrain from any activity that loads the joints. Intensive physical activity should be limited within 48 hours after the procedure. To obtain optimal treatment effects, it is recommended to use 1 treatment tube per joint.
Perform intradermal injections using aseptic techniques and precautions. The obtained concentrate should be implanted directly into the deep layers of the dermis with the use of needle mesotherapy using the nappage or micro-deposit technique, and in places requiring special regeneration using the back-linear technique. To obtain optimal treatment effects, it is recommended to use 1 tube per treatment area. Due to the hygroscopic abilities of hyaluronic acid and the risk of potential swelling, it is not recommended to apply the solution directly to the eye area.
The external use of PRP plate concentrate is possible in conjunction with other aesthetic medicine procedures (e.g., microneedle mesotherapy, fractional laser). Apply the obtained product epidermally after damaging the skin.
Injections of FUSION PRP concentrate may cause redness, swelling, pain or slight bruising at the treatment site. Usually, these changes are mild and disappear after a few days. To obtain optimal correction effects and safe convalescence:
– do not apply makeup for up to 12 hours
– avoid solarium and excessive sun exposure for up to 2 weeks after the procedure
– do not expose the correction site to extreme low and high temperatures
– apply ointments that seal blood vessels to the places where bruising occurred
– immediately report any disturbing changes to the specialist performing the procedure
DIVES MED FUSION PRP may only be used by physicians and medical personnel with specialized training in the techniques of using therapy with autologous blood products. Before use, familiarize yourself with the purpose and method of use of the set. Before starting the procedure, it is absolutely necessary to conduct a medical interview, rule out contraindications, obtain informed consent to perform the procedure and inform the patient about possible results and possible side effects. During the implantation of the product, the procedure and the injection site should be fully aseptic. Do not inject intravenously or use for other purposes. Due to the hygroscopic abilities of hyaluronic acid and the risk of potential swelling, it is not recommended to apply the solution directly to the eye area. The contained separating gel is not intended for injection and should not be administered into tissues. Single-use test tube and instruments. Do not re-use and do not re-sterilize. Do not use after the expiration date. Incorrect or inconsistent with the manufacturer’s recommendations may lead to complications and side effects.
POSSIBLE SIDE EFFECTS:
DIVES MED PRP injections may lead to slight damage to blood vessels and the formation of hematomas and bruises. Swelling and redness may occur in the treatment area immediately after injection, as well as a short-term secondary inflammatory reaction. Isolated allergic reactions have been reported in the case of unwanted injection of a separating gel.
The DIVES MED – FUSION PRP set contains 2 treatment sets for single use. Dispose of all used surgical instruments in a container for medical waste. After use, dispose of all components of the set according to instructions for the handling of potentially blood-contaminated materials. Use caution from unguarded needles and other contaminated surgical instruments. Do not put used needles back into the needle cap.
The contents of the blisters have been sterilized by radiation.
SHELF LIFE AND STORAGE:
Store at 2oC-28oC, away from sunlight and heat sources. Do not use the product after the expiry date and if the blister is damaged or incorrectly stored. Use the contents of the blister and the treatment instruments for a single application and do not re-sterilize.